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// research project · 02

smFRET —
NAC & RNC_

smFRETTIRF MicroscopyNACDeepFRET
institution Caltech
lab Shan Lab, CCE
period Jun – Sep 2024 (SURF)
status published · Mol. Cell 2026

// overview

The nascent polypeptide-associated complex (NAC) is a conserved ribosome-associated chaperone that promotes co-translational protein folding. In this project we used single-molecule FRET to probe how NAC interacts with nascent chain and helps in co-translational protein folding.

// links