pratiman@caltech:~$
$ whoami
Pratiman De

// hello! I'm

Pratiman De

> contact me
01

about_me

/** Bio */

I'm a second-year PhD student in Chemistry (Chemical Biology & Molecular Biosciences) at Caltech, with a strong interdisciplinary background in spectroscopy, imaging, computation, and molecular biology. My Integrated M.Sc. thesis at NISER Bhubaneswar focused on developing machine learning models for signal processing in NMR spectroscopy.

/* Chemical Biology & Molecular Biosciences */

// education
2025–PhD ChemistryCaltech
2020–2025Int. M.Sc. ChemistryNISER
// research interests
Machine Learning Protein Biogenesis Microscopy & Image Processing NMR Spectroscopy
02

publications_

/* sorted by year, descending */

2026 preprint

Overcoming sensitivity barrier in ¹³C NMR using frequency–time dual-domain GANs: Quantitative reaction monitoring at natural abundance

De, P., Mishra, S., & Ghosh, A.

ChemRxiv, 2026

DOI ↗
2026 journal

NAC promotes co-translational protein folding at the ribosomal tunnel exit

Santos, J., Günnigmann, M., Gora, R. J., Iljina, M., Predin, M., Kotan, I. E., De, P., Choudhary, D., Jang, J., Tippmann, F., Hins, C., Ban, N., Tans, S. J., Shan, S.-o., Kramer, G., & Bukau, B.

Molecular Cell, 2026

DOI ↗
2026 preprint

Transient contractility attenuation reprograms epithelial cells into a protrusion-driven state that drives tissue fluidization

Sound, W. P., Liu, S., Nguyen, T. P., Mishra, P. K., De, P., Gupta, A. S., & Hirashima, T.

bioRxiv, 2026

DOI ↗
03

experience_

// research positions

Aug 2023–Jul 2025 thesis

M.Sc. Thesis — AG Lab

School of Chemical Sciences, NISER Bhubaneswar — Dr. Arindam Ghosh

1. Reaction monitoring through natural abundance ¹³C NMR using GAN-based dual-domain denoising (FTDD-GAN).
2. Diagonal suppression in COSY using ML.

→ ML in NMR Spectroscopy
Jun–Sep 2024 SURF

Caltech SURF Fellow

Shan Lab, Division of Chemistry & Chemical Engineering, Caltech

Study of conformational dynamics and regulation in NAC (chaperone) & optimization of DeepFRET model for smFRET data analysis.

→ smFRET — NAC & RNC
May 2023–Jun 2024 internship

MBI MUST Programme

Hirashima Group, Mechanobiology Institute (MBI), NUS Singapore

Study of collective cell migration under drug treatment. Developed image analysis pipelines for FRET analysis, cell tracking, and vertex modeling.

→ Collective Cell Migration
Dec 2022–Aug 2023 research

Undergraduate Researcher

Srivastava's Lab, Molecular Biophysics Unit, IISc Bangalore

Reaction-diffusion (RD) simulation to study nanodomain kinetics of neuronal membrane using NERDSS.

Jun–Jul 2022 summer

Summer Project Fellow

AJ Lab, Nanobiotechnology Group, IIT Mandi

Synthesis and characterization of plasmonic nanoparticles and their application in photothermal therapy (PTT).

May–Jun 2022 NIUS

NIUS Physics Research Student

Semiconductor Optoelectronics Group, TIFR Mumbai — Prof. Arnab Bhattacharya

Synthesis and characterization of rhenium-based semiconductor material.

04

contact_me

// get in touch

I'm always open to discussing research collaborations, internships, or just chatting about science!

emailpratiman.de@caltech.edu
linkedin/in/pratiman-de
githubpratiman-de